Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82

Deprecated: strpos(): Non-string needles will be interpreted as strings in the future. Use an explicit chr() call to preserve the current behavior in /www/wwwroot/4-16.com/label.php on line 82
heyzo大桥未久持续中出:开启你的娱乐之旅,发现最热最全的影视资源,尽在掌握!
随机图片

heyzo大桥未久持续中出:开启你的娱乐之旅,发现最热最全的影视资源,尽在掌握!

更新时间: 浏览次数: 449

400电话:123456(点击咨询)
heyzo大桥未久持续中出:开启你的娱乐之旅,发现最热最全的影视资源,尽在掌握!各观看免费《今日汇总》
heyzo大桥未久持续中出:开启你的娱乐之旅,发现最热最全的影视资源,尽在掌握!各热线观看免费2025已更新(2025已更新)








heyzo大桥未久持续中出:开启你的娱乐之旅,发现最热最全的影视资源,尽在掌握!观看免费电话:(1)123456(点击咨询)(2)123456(点击咨询)








heyzo大桥未久持续中出:开启你的娱乐之旅,发现最热最全的影视资源,尽在掌握!观看免费热线(1)123456(点击咨询)(2)123456(点击咨询)




heyzo大桥未久持续中出:开启你的娱乐之旅,发现最热最全的影视资源,尽在掌握!各区点热线观看免费《今日发布》
Random Image heyzo大桥未久持续中出:开启你的娱乐之旅,发现最热最全的影视资源,尽在掌握!电话








7天观看免费人工电话为您、heyzo大桥未久持续中出:开启你的娱乐之旅,发现最热最全的影视资源,尽在掌握!团队在调度中心的统筹调配下,线下专业及各地区人员团队等专属,整个报修流程规范有序,后期同步跟踪查询公开透明。








所有团队均经过专业培训、持证上岗,所用产品配件均为原厂直供,








heyzo大桥未久持续中出:开启你的娱乐之旅,发现最热最全的影视资源,尽在掌握!各观看免费《今日汇总》2025已更新(今日/推荐)








heyzo大桥未久持续中出:开启你的娱乐之旅,发现最热最全的影视资源,尽在掌握!电话区域:








武威市(古浪县、凉州区、天祝藏族自治县、民勤县)








常德市(澧县、安乡县、桃源县、津市市、临澧县、武陵区、鼎城区、汉寿县、石门县)








果洛藏族自治州(久治县、玛多县、达日县、甘德县、班玛县、玛沁县)








固原市(泾源县、西吉县、隆德县、原州区、彭阳县)  迪庆藏族自治州(德钦县、香格里拉市、维西傈僳族自治县)








台州市(临海市、椒江区、玉环市、路桥区、仙居县、天台县、温岭市、黄岩区、三门县)








南充市(南部县、蓬安县、阆中市、营山县、仪陇县、西充县、嘉陵区、高坪区、顺庆区)








海西蒙古族藏族自治州(天峻县、茫崖市、德令哈市、格尔木市、都兰县、乌兰县)








锦州市(北镇市、义县、太和区、黑山县、凌海市、凌河区、古塔区)  株洲市(炎陵县、石峰区、天元区、芦淞区、攸县、醴陵市、茶陵县、荷塘区、渌口区)








连云港市(灌云县、海州区、赣榆区、连云区、灌南县、东海县)








盘锦市(兴隆台区、双台子区、大洼区、盘山县)








河池市(天峨县、罗城仫佬族自治县、宜州区、都安瑶族自治县、巴马瑶族自治县、南丹县、环江毛南族自治县、东兰县、凤山县、大化瑶族自治县、金城江区)








汕尾市(海丰县、城区、陆丰市、陆河县)








锡林郭勒盟(二连浩特市、正蓝旗、正镶白旗、太仆寺旗、多伦县、东乌珠穆沁旗、苏尼特右旗、镶黄旗、阿巴嘎旗、苏尼特左旗、西乌珠穆沁旗、锡林浩特市)








长春市(二道区、德惠市、南关区、双阳区、宽城区、农安县、公主岭市、九台区、榆树市、朝阳区、绿园区)








福州市(闽清县、连江县、长乐区、晋安区、闽侯县、马尾区、鼓楼区、仓山区、福清市、台江区、平潭县、永泰县、罗源县)








临沂市(蒙阴县、兰陵县、平邑县、沂水县、费县、兰山区、河东区、罗庄区、沂南县、莒南县、郯城县、临沭县)








双鸭山市(友谊县、集贤县、尖山区、宝清县、四方台区、宝山区、饶河县、岭东区)








张家口市(康保县、桥西区、下花园区、赤城县、沽源县、崇礼区、尚义县、怀安县、蔚县、涿鹿县、宣化区、万全区、怀来县、阳原县、张北县、桥东区)








宜宾市(长宁县、屏山县、叙州区、高县、翠屏区、江安县、南溪区、兴文县、筠连县、珙县)








焦作市(修武县、温县、山阳区、中站区、马村区、博爱县、解放区、武陟县、沁阳市、孟州市)








厦门市(翔安区、海沧区、同安区、思明区、集美区、湖里区)








昌吉回族自治州(昌吉市、奇台县、木垒哈萨克自治县、呼图壁县、吉木萨尔县、阜康市、玛纳斯县)








杭州市(萧山区、临安区、上城区、拱墅区、滨江区、西湖区、建德市、淳安县、桐庐县、余杭区、钱塘区、富阳区、临平区)








红河哈尼族彝族自治州(元阳县、绿春县、弥勒市、个旧市、屏边苗族自治县、金平苗族瑶族傣族自治县、建水县、河口瑶族自治县、泸西县、蒙自市、红河县、开远市、石屏县)








湛江市(坡头区、吴川市、遂溪县、廉江市、赤坎区、徐闻县、霞山区、麻章区、雷州市)








铜川市(宜君县、王益区、耀州区、印台区)








安庆市(大观区、迎江区、太湖县、宿松县、潜山市、宜秀区、桐城市、怀宁县、望江县、岳西县)
400电话:123456(点击咨询)
heyzo大桥未久持续中出:开启你的娱乐之旅,发现最热最全的影视资源,尽在掌握!各观看免费《今日汇总》《今日发布》
heyzo大桥未久持续中出:开启你的娱乐之旅,发现最热最全的影视资源,尽在掌握!各观看免费《今日汇总》(2025已更新)








heyzo大桥未久持续中出:开启你的娱乐之旅,发现最热最全的影视资源,尽在掌握!观看免费电话:(1)123456(点击咨询)(2)123456(点击咨询)








heyzo大桥未久持续中出:开启你的娱乐之旅,发现最热最全的影视资源,尽在掌握!观看免费热线(1)123456(点击咨询)(2)123456(点击咨询)




heyzo大桥未久持续中出:开启你的娱乐之旅,发现最热最全的影视资源,尽在掌握!各观看免费《今日汇总》【2025已更新列表】
heyzo大桥未久持续中出:开启你的娱乐之旅,发现最热最全的影视资源,尽在掌握!电话








7天观看免费人工电话为您、heyzo大桥未久持续中出:开启你的娱乐之旅,发现最热最全的影视资源,尽在掌握!团队在调度中心的统筹调配下,线下专业及各地区人员团队等专属,整个报修流程规范有序,后期同步跟踪查询公开透明。








所有团队均经过专业培训、持证上岗,所用产品配件均为原厂直供,








heyzo大桥未久持续中出:开启你的娱乐之旅,发现最热最全的影视资源,尽在掌握!中心2025已更新(今日/推荐)








heyzo大桥未久持续中出:开启你的娱乐之旅,发现最热最全的影视资源,尽在掌握!电话区域:








咸阳市(乾县、三原县、杨陵区、兴平市、渭城区、永寿县、礼泉县、泾阳县、淳化县、秦都区、旬邑县、彬州市、武功县、长武县)








山南市(错那市、曲松县、浪卡子县、扎囊县、措美县、洛扎县、隆子县、乃东区、琼结县、贡嘎县、加查县、桑日县)








郴州市(安仁县、汝城县、苏仙区、临武县、桂东县、桂阳县、北湖区、资兴市、嘉禾县、宜章县、永兴县)








白山市(靖宇县、浑江区、江源区、临江市、抚松县、长白朝鲜族自治县)  贵港市(桂平市、平南县、覃塘区、港南区、港北区)








成都市(彭州市、简阳市、龙泉驿区、武侯区、新津区、都江堰市、新都区、蒲江县、金牛区、崇州市、大邑县、邛崃市、成华区、郫都区、金堂县、锦江区、青羊区、青白江区、温江区、双流区)








昭通市(彝良县、绥江县、永善县、巧家县、大关县、镇雄县、盐津县、昭阳区、水富市、鲁甸县、威信县)








揭阳市(普宁市、惠来县、榕城区、揭西县、揭东区)盐城市(阜宁县、亭湖区、射阳县、东台市、响水县、盐都区、滨海县、建湖县、大丰区)








六盘水市(钟山区、盘州市、水城区、六枝特区)  绥化市(青冈县、兰西县、肇东市、北林区、望奎县、海伦市、安达市、庆安县、明水县、绥棱县)








凉山彝族自治州(宁南县、美姑县、盐源县、金阳县、德昌县、会理市、西昌市、会东县、布拖县、普格县、昭觉县、木里藏族自治县、冕宁县、喜德县、甘洛县、越西县、雷波县)








桂林市(雁山区、象山区、永福县、龙胜各族自治县、兴安县、叠彩区、全州县、七星区、灌阳县、恭城瑶族自治县、荔浦市、灵川县、临桂区、阳朔县、资源县、秀峰区、平乐县)








金昌市(永昌县、金川区)西宁市(湟源县、城西区、湟中区、大通回族土族自治县、城北区、城中区、城东区)








张掖市(民乐县、肃南裕固族自治县、临泽县、甘州区、高台县、山丹县)








信阳市(商城县、淮滨县、光山县、新县、罗山县、固始县、息县、潢川县、浉河区、平桥区)








贵阳市(南明区、修文县、白云区、花溪区、清镇市、云岩区、息烽县、乌当区、观山湖区、开阳县)








营口市(鲅鱼圈区、西市区、盖州市、大石桥市、老边区、站前区)








中卫市(海原县、中宁县、沙坡头区)








玉溪市(易门县、江川区、元江哈尼族彝族傣族自治县、澄江市、通海县、华宁县、峨山彝族自治县、新平彝族傣族自治县、红塔区)








东莞市








淮南市(寿县、八公山区、潘集区、田家庵区、谢家集区、大通区、凤台县)








青岛市(市南区、李沧区、崂山区、城阳区、平度市、即墨区、莱西市、黄岛区、市北区、胶州市)








防城港市(上思县、东兴市、防城区、港口区)








伊犁哈萨克自治州(霍城县、昭苏县、奎屯市、察布查尔锡伯自治县、伊宁市、尼勒克县、伊宁县、霍尔果斯市、巩留县、特克斯县、新源县)








汉中市(宁强县、勉县、洋县、镇巴县、汉台区、城固县、南郑区、留坝县、西乡县、略阳县、佛坪县)








广州市(海珠区、荔湾区、越秀区、白云区、黄埔区、增城区、从化区、番禺区、天河区、花都区、南沙区)








邢台市(内丘县、临城县、临西县、宁晋县、襄都区、南宫市、威县、沙河市、隆尧县、平乡县、信都区、南和区、巨鹿县、广宗县、清河县、任泽区、柏乡县、新河县)








淮北市(相山区、杜集区、濉溪县、烈山区)








毕节市(黔西市、大方县、七星关区、威宁彝族回族苗族自治县、织金县、金沙县、赫章县、纳雍县)

4月18日,康华生物(维权)(300841)发布2024年年报,公司全年实现营业收入14.32亿元,扣非净利润4.57亿元。作为A股代表性创新型疫苗企业,康华生物的重组六价诺如病毒疫苗成功实现对外授权(license-out),并有望成为继人二倍体细胞狂犬病疫苗之后公司下一个“王牌产品”。

2024年,受疫苗降价、人口出生率下降等因素影响,疫苗企业业绩面临回调压力。2024年前三季度,A股14家疫苗上市公司中有10家“营利双降”,近期已披露2024年年报的疫苗企业中,主营HPV疫苗、流感疫苗的多家上市公司营收和净利润均大幅下滑。

在此背景下,康华生物业绩基本维持稳定,公司持续推进创新研发,实现技术出海,并在行业调整期进一步深化品牌和渠道建设,以疫苗产品核心竞争优势为出发点,不断提高市场覆盖率并促进渠道下沉。

当前,新型疫苗不断升级迭代,针对未满足需求的重磅疫苗陆续上市,在国产疫苗加速“出海”,创新疫苗国产替代趋势持续演进的背景下,康华生物将聚焦重点研发项目,促进研发成果落地,推动公司未来实现可持续增长。

六价诺如病毒疫苗“出海”商业化进程提速

2024年是康华生物成立20周年,经过长期技术积累的康华生物也在创新型疫苗领域实现重大突破,不仅实现技术出海,也为公司经营开启了新的增长点。

2024年1月,康华生物与国际疫苗企业hillevax签署独家许可协议,授权HilleVax在除中国(含港澳台)以外地区对重组六价诺如病毒疫苗及其衍生物进行开发、生产与商业化,交易金额包括首付款1500万美元,最高2.555亿美元的开发里程碑和销售里程碑款项,以及实际年净销售额个位数百分比的特许权使用费,创下中国疫苗License-out金额之最。

诺如病毒是全球急性胃肠炎的主要病原体,每年导致近7亿人感染、20万人死亡,但至今尚无疫苗上市,传统研发路径因病毒变异快、体外培养难而屡屡受挫。康华生物通过收集流调信息,和公共卫生专家、流行病学专家集中探讨,最终选定了六种诺如病毒主要流行基因型,开发重组六价诺如病毒疫苗,由此也成为在研价次最高的多价诺如病毒疫苗之一。

针对未满足需求的创新疫苗产品,也意味着良好的商业前景。诺如病毒感染性腹泻在全世界范围内均有流行,在国内,据中国国家疾控中心信息,每年10月到次年3月是我国诺如病毒感染高发季节,是导致急性胃肠炎的最常见病原体之一,国内多地也曾发生群体感染事件。据FrostSullivan的数据,随着中国诺如病毒疫苗管线研发进度和临床进度的推进,预计最早2026年将有相关产品获批上市;2026-2031年,中国诺如病毒疫苗市场规模可由15.3亿元增长至229.3亿元,年复合增长率达71.85%。

康华生物年报披露,公司重组六价诺如病毒疫苗在2024年12月取得国内临床试验许可,此外,ACYW135群脑膜炎球菌结合疫苗、人用狂犬病疫苗(人二倍体细胞)固定化生物反应器培养工艺计划在2025年申报临床试验。

对于康华生物而言,无论是为公司持续贡献业绩的人用狂犬病疫苗,还是加速迈向商业化的重组六价诺如病毒疫苗,都是“含金量”极高的大单品,尽管在医药控费等因素影响下疫苗市场存在一定起伏,但随着人口老龄化、公众接种意识提高,相关品种疫苗仍有着很大的渗透空间,这也为康华生物未来持续增长奠定坚实基础。

长期主义凸显增长潜力“耐心资本”增持

疫苗行业呈现研发周期长、资金投入大且生产及质控要求高的特点,使疫苗行业具有较高壁垒,呈现寡头垄断格局。这也决定了疫苗企业唯有坚持长期主义,持续投入研发创新和开拓市场才能获得可持续回报。

长期以来,默沙东、葛兰素史克、辉瑞等国际领先疫苗企业占据全球疫苗市场的大部分份额,如13价肺炎球菌多糖结合疫苗、HPV疫苗等重磅产品上市十余年后,销售额依然位居前列。对于中国本土疫苗企业而言,未来增长空间一方面在于国产替代,以高质量本土产品替代进口疫苗,与此同时,面向发达国家和发展中国家市场的“出海”,也将为本土疫苗企业开拓新空间。

在国产替代方面,2021年出台的《“十四五”国家药品安全及促进高质量发展规划》提出,支持疫苗领域创新发展,推动关键核心技术攻关,促推解决产业创新发展的“卡脖子”问题,部分本土疫苗企业在这方面已有成功案例。值得注意的是,中国人均疫苗发展公共支出相对较低,随着国民健康意识提高,相关研究指出,中国疫苗行业相较发达国家仍有2-8倍增长空间。

在国产疫苗“出海”方面,除向发展中国家输出疫苗外,如康华生物的重组六价诺如病毒疫苗成功实现了向发达国家的技术输出,堪称近年来创新疫苗出海的典型案例。

正是着眼于疫苗市场的广阔市场空间,康华生物已布局mRNA疫苗平台、重组蛋白VLP疫苗平台、多糖蛋白结合疫苗平台、减毒活疫苗平台、灭活疫苗平台、新型疫苗佐剂平台等多个创新疫苗平台,循序渐进推进相关管线的研发和商业化。未来,包括新疫苗品种的推出,以及疫苗产品迭代,都将成为创新疫苗企业的新增长点。

事实上,着眼康华生物的良好发展前景,2024年下半年以来已有多家“耐心资本”加持康华。

年报显示,截止2024年12月31日,相较于上一报告期,新进的流通股东中,四川国资“四川发展证券投资基金管理有限公司-川发精选3号私募证券投资基金”本期持有807.9万股,占流通股比例6.7%。增持的股东中,社保基金422组合本期较上期自持股份增持38.08%至197.04万股。一季报显示,截止2025年3月31日,新进的流通股东中,北向资金本期持有182.7万股,占流通股比例1.52%。

4月18日,康华生物在发布年报及一季报的同时,发布公告称拟将回购账户中的300万股用途由“用于实施员工持股计划或股权激励”,变更为“用于注销并相应减少注册资本”。股份注销通常被视为公司对自身价值的高度认可,有助于提升每股收益(EPS)和股东权益回报率(ROE),亦显示了康华生物对自身长期价值的信心。

heyzo大桥未久持续中出:开启你的娱乐之旅,发现最热最全的影视资源,尽在掌握!的相关文章 儿童请勿在半夜踏足这片森林,这里已经被诅咒了!的相关文章
酷似张翰网红称直播打螺丝赚几百万
汉堡常年称霸德乙为什么上不来德甲?
克宫:协议已失效 普京未下令
美联储官员:利率或维持高位更久
下雨天适合睡觉的原因找到了
宝妈5个月没睡过整觉查出胃癌晚期
印小天化身卓别林亮相北影节红毯
网传郑州将禁止早晚遛狗?官方回应
九部门发文促家政服务消费扩容:满足共享保洁烹饪接送等需求
言短意长|郑州大学教授范冰冰遭遇标题党
13个简单有趣的小食谱~有手就会系列
习近平结束国事访问回到北京
  • 友情链接:
  • 特斯拉销售称全周无休仍卖不出去车 横扫11项奥斯卡!39年后才被打破纪录,万字解析无法复制的旷世杰作,这辈子再也看不到第二部了《宾虚》 女子踏青患怪病高烧呕吐多器官损害 伊朗总参谋长愿深化与沙特军事合作 倪妮北影节走了两次红毯 抽烟、吃香蕉和在核电站工作的辐射量谁更大 白龙幻想1-9纯享版!没看过的有福了 九部门发文促家政服务消费扩容:满足共享保洁烹饪接送等需求 张远抽中张杰演唱会第一个定制应援棒 杭铁回应地铁口被吐槽像棺材,称设计灵感源于「虫洞」形象,如何看待这一设计?建筑设计如何保证大众接受度? 4 月 18 日澳门世界杯男单 1/4 决赛,林诗栋 4-0 莫雷加德,如何评价本场比赛?

    查看更多评价 ∨