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揉碎(骨科 1v2)讲的什么,一场关于爱与复仇的豪门恩仇录
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揉碎(骨科 1v2)讲的什么,一场关于爱与复仇的豪门恩仇录

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热点栏目自选股数据中心行情中心资金流向模拟交易客户端

  南山铝业国际(02610)公布,于2025年4月19日(星期六),招股章程所述的超额配股权已获独家整体协调人代表国际包销商按每股股份26.60港元部分行使,涉及合共119.99万股股份,相当于全球发售项下可供认购发售股份总数约1.36%(并未计及超额配股权的任何行使),以补足国际配售的超额分配。

  根据香港法例第571W章证券及期货(稳定价格)规则第9(2)条,公司宣布,全球发售的稳定价格期间已于2025年4月19日(星期六)(即于递交香港公开发售申请的截止日期后第30日)结束。

  有关华泰金融控股(香港)有限公司(稳定价格经办人)或其联属人士或代其行事的任何人士于稳定价格期间进行的稳定价格行动载列如下:

  (i)国际配售中超额分配合共1323.52万股股份,相当于全球发售项下可供认购发售股份总数的约15.0%(并未计及超额配股权的任何行使);

  (ii)根据借股协议向NAIHL借入合共1323.52万股股份,以补足国际配售的超额分配;

  (iii)于稳定价格期间在市场上按每股股份20.4港元至26.6港元的价格连续买入合共1203.53万股股份,相当于全球发售项下可供认购发售股份总数约13.64%(并未计及超额配股权的任何行使)。稳定价格经办人或其联属人士或代其行事的任何人士于稳定价格期间在市场上作出的最后一次买入为2025年4月17日,价格为每股股份26.55港元;及

  (iv)独家整体协调人(代表国际包销商)于2025年4月19日(星期六)按全球发售最终发售价每股股份26.60港元部分行使超额配股权,涉及合共119.99万股股份,相当于全球发售项下可供认购发售股份总数约1.36%(并未计及超额配股权的任何行使),以补足国际配售的超额分配。

  独家整体协调人代表国际包销商尚未行使的部分超额配股权于2025年4月19日(星期六)失效。

  当地时间4月22日,美国三大股指收涨。截至收盘,道指涨2.66%,标普500指数涨2.51%,纳指涨2.71%。

  纳斯达克中国金龙指数涨超3%,盘中一度涨超4%,万得中概科技龙头指数涨超4%。热门中概股方面,比特小鹿涨逾23%,禾赛科技、和黄医药涨逾12%,阿里巴巴涨逾5%。

  大宗商品市场方面,伦敦现货黄金、COMEX黄金期货价格一度双双站上3500美元/盎司,均再次创下历史新高,随后均转跌,日内均较最高点回落超100美元/盎司。截至北京时间4月23日6:00,伦敦现货黄金价格报3379.37美元/盎司,跌1.3%;COMEX黄金期货报3392美元/盎司,跌0.97%。

热点栏目自选股数据中心行情中心资金流向模拟交易客户端

  比亚迪股份(01211)早盘高开逾6%,截至发稿,股价上涨3.73%,现报389.80港元,成交额14.90亿港元。

  比亚迪股份公布2024年度利润分配及资本公积金转增股本方案,拟向全体股东每10股派发现金红利人民币39.74元(含税),现金红利总额约为约人民币120.77亿元,每10股送红股8股,以资本公积金每10股转增12股。本次送红股及资本公积金转增股本方案实施后,比亚迪总股本将由30.39亿股增加至91.17亿股。

  来源:健康元药业集团

  在全球医药产业加速向创新驱动转型的背景下,创新药物研发已经成为国内制药企业竞争的核心。健康元药业(600380.SH)顺应这一趋势,凭借前瞻性的研发布局和技术突破,正逐步从传统的制剂企业转型为创新药的先锋。2024年,健康元(不含丽珠集团、丽珠单抗)研发费用同比增长30%,同时在流感治疗、慢病管理等领域形成差异化竞争优势。

  研发投入结构优化,创新药占比再提高

  健康元在2024年大幅优化研发投入结构,创新药研发投入占比再提高。这一战略调整背后,是公司对“技术储备”到“商业兑现”全链条的深度布局。随着国家政策的支持不断增强,健康元在多个关键领域加大了技术攻关,创新药领域多个项目进展顺利,健康元的创新药管线有望进一步巩固市场领先地位。投资者的目光集中在其逐步成熟的药物管线和未来市场前景上,公司有望在未来五年内跻身国内兼具技术深度与市场广度的创新药企第一梯队。

  多元化研发管线:

  呼吸药物与流感治疗的双重突破

  健康元的创新药研发管线涵盖多个重要领域,其中呼吸药物无疑是最为瞩目的。数据显示,我国COPD患者已超过1亿,哮喘患者超过6000万。弗若斯特沙利文数据显示,中国呼吸疾病市场规模预计2033年将突破千亿元,市场空间广阔。

  作为国内吸入制剂领域的先行者,健康元已形成“吸入制剂+生物药+AI技术”的三维创新体系,推出了一系列具有自主知识产权的吸入制剂。特别是TSLP单抗,这款针对中重度COPD的靶向生物药,已经进入Ⅱ期临床,填补了国内市场的空白,未来有望成为全球市场的重磅产品。

  此外,健康元在流感治疗领域的创新也展现了巨大的市场潜力。玛帕西沙韦作为流感1类创新药,将凭借乙流缓解更迅速、青少年患者受益显著、全程仅需单次口服的三大核心优势颠覆传统治疗模式。随着Ⅲ期临床的顺利推进,玛帕西沙韦有望成为治疗流感的核心药物,抢占百亿级市场份额。

  健康元还在镇痛药领域布局了Nav1.8抑制剂,这款非阿片类创新药物因其无成瘾性和高效镇痛的特点,受到市场广泛关注,预计将在未来几年内成为一个突破性的药物。

  创新药兑现周期即将开启:

  平台型赋能,未来可期

  目前,健康元正推进创新研发的自研与引进双轨发展,强化创新药布局,同时进一步推进药品海外注册申报及国际市场的开发。通过公司强大的研发平台和技术积累,不仅在呼吸领域取得了成果,还在其他领域逐步拓展。AI技术的引入加快了健康元在研发效率和创新速度,为未来的产业化和市场化奠定坚实基础。

  通过不断推动技术平台的搭建,以AI技术深度赋能医药创新,在研发创新、生产质控、精准营销、职能管理四大核心领域实现全链条数字化升级。正如海通证券和光大证券的研报所指出,健康元的创新药已经具备了“制剂领先+创新放量+医保入围”的三重优势,正在进入业绩兑现的窗口期。

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